CAR Design_Synthetic Biology, Senior and Principal Scientist

Contract Type: Permanent
Location: Galway
Contact Name: Larry O’Leary
Contact Email: larry@rftgroup.ie

Job Description

Principal Scientist, CAR Design/Synthetic Biology
Our client, an innovative cell therapy company dedicated to the development of chimeric antigen receptor (CAR) cell therapies for haematology and oncology diseases, now seek to hire Principal Scientists and Senior Scientists their rapidly expanding team.

These roles will support the company’s development strategy in optimising NK cell therapy through the drug development framework for their NK cell & gene therapy programs:
  • CAR Optimisation & Selection,
  • Gene Editing & Cell Engineering,
  • In-Vitro & In-Vivo characterization and finally
  • In-Vivo characterization
The successful candidates, Principal Scientists and Senior Scientists level, will be responsible for establishing infrastructure, participating in developing strategies, techniques, and approaches in support of consolidating current NK cell therapy programs and developing next generation ideas and products.

These hires will have experience with novel cellular technologies, in vitro and in-vivo evaluation of modalities in an oncology setting and experience with approaches for gene editing or acumen to pick these up is important.

These hires will assist and provide leadership in company efforts to develop next generation chimeric antigen receptor (CAR) based NK cellular therapies to support company pipelines. The scientist will help optimize and select lead CAR designs to enhance NK cell functions in-vitro and contribute to design of in-vivo CAR-NK experiments. At Principal Scientist level the individual will lead these efforts.

Person fit; high level qualifications and relevant cell therapy experience with ability to be flexible, innovative and highly organized to work quickly and efficiently in a growing biotech start-up environment is required.

Responsibilities of these roles:
  • Contribute to the establishment of laboratory capability and laboratory systems.
  • Provides input into developing research work plan and associated experiments.
  • Input into identifying technical and quality requirements required to complete work plan.
  • Other duties as required, in line with a start-up biotechnology environment, maximum flexibility is essential.
  • Develop, execute, and document strategies for isolating and modifying primary NK cells.
  • Demonstrate exceptional skills at handling NK cells.
  • Has cell culture experience that includes handling of primary cells.
  • Highly proficient in molecular and cell biology
  • Experience with oncology-targeting experiments in mice models or ability to pick these up rapidly.
  • Capability to work with nucleic acid constructs and modification of effector lymphocytes.
Team focused (Principal Scientist)
  • Lead development of next generation CAR products and optimisation of CAR design, constructs and related engineering (Principal Scientist)
  • Senior member of the scientific team responsible for managing a team of scientists.
  • Effectively communicate scientific results to a technical and non-technical audience.
  • Experience with guiding junior level research associates
  • Contribute to building out team, establishment of laboratory capability and lab systems.
Project Management/Planning (Principal Scientist)
  • Lead discrete project work streams within own discipline
  • Input into developing research work plan and associated experiments.
  • Management of study planning to deliver on milestones.
  • Responsible for identifying technical and quality requirements required to complete work plan.
  • Planning conduct and reporting of experiments.
Requirements for these roles:
  • MSc or PhD in immunology and lymphocyte biology with post-doc experience.
  • Alternatively, Bachelor's with at least 2 years of experience, preferably in an industry environment in one of the following disciplines: cancer cellular therapy, cancer immunology, immunology, or related field.
  • Prior experience with cellular therapies is important. Experience with developing lymphocyte-based cell therapies, especially in an industry setting would be preferred. Experience of working with NK cells, including isolation, culture, differentiation/activation, cell transfection and transduction is desirable.
  • Thorough understanding of CAR based cell therapy; a working knowledge of CAR engineering and both in vitro and in vivo cell therapy assays is preferred (essential for Principal Scientist)
  • Previous experience in NK or CAR-T based cancer therapy (essential for Principal Scientist)
  • Proficient in immune phenotyping of cultured immune cells using multi-color FACs and FlowJo-based data analysis
  • Capability to work with nucleic acid constructs and modification of effector lymphocytes.
Please phone Larry on +353 (0)1-2302400 / larry@rftgroup.ie

The RFT Group, BioPharmaceutical Division specialise exclusively in the recruitment of scientists, engineers and executives for the biotechnology, pharmaceutical and medical device sectors. www.rftgroup.ie

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